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ORIGINAL ARTICLE
Year : 2013  |  Volume : 3  |  Issue : 2  |  Page : 114-120

Effect of Vimliv on lipid profile and histopathology in ethanol-induced hepatotoxicity in albino Wistar rats


Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram, Namakkal Dist., Tamil Nadu, India

Correspondence Address:
Murugan Rajadurai
Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram - 637 408, Namakkal Dist., Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.112831

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Background: Liver disease is considered to be a serious health problem, as the liver is an important organ for the detoxification and deposition of endogenous and exogenous substances. Objective: The present study is carried out to investigate the effect of Vimliv in ethanol-induced hepatotoxicity. Materials and Methods: Ethanol (3 g/kg) was dissolved in water and injected intragastrically, for a period of 35 days. Vimliv was dissolved in carboxy methyl cellulose and administered to rats at doses of 25 and 50 mg/kg for a period of 35 days as coadministration. Results: Administration of Vimliv resulted in significant reduction of blood glucose, serum urea, creatinine, lipid profile and increase in albumin. Administration of Vimliv also shows better pathological effects on liver and kidney. Conclusion: Therefore, this study suggests that Vimliv has the hepatoprotective effect and consequently may alleviate liver and renal damage associated with ethanol-induced hepatotoxicity in rats.


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