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ORIGINAL ARTICLE
Year : 2013  |  Volume : 3  |  Issue : 2  |  Page : 102-107

A study on the hematological parameters and brain acetylcholine esterase activity in immobilization induced stress and co-treatment with Centella asiatica leaves extract to wistar rats


1 Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India
2 Division of Biochemistry, Rani Meyyammai College of Nursing, Faculty of Medicine, Annamalai University, Annamalai Nagar, Tamil Nadu, India

Correspondence Address:
Nadanam Saravanan
Division of Biochemistry, Rani Meyyammai College of Nursing, Faculty of Medicine, Annamalai University, Annamalai nagar - 608 002, Tamilnadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.112829

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Aim: Our aim was to evaluate the anti-stress activities of aqueous leaf extract of Centella asiatica (CA) in immobilization-induced stress in rats. The anti-stress activities of CA were assessed by monitoring the changes in the behavior, counts of red blood cells (RBCs) and white blood cells (WBCs) (Lymphocytes, Monocytes, Neutrophils, Esinophils) and change in the level of brain acetylcholine esterase (AChEs) activity in immobilization-induced stress in male albino Wistar rats. Materials and Methods: Immobilization stress was induced in rats by placing in 20 cm × 7 cm plastic tubes for 2 h/day for 21 days. Aqueous leaf extract of CA was co-administered orally to the experimental rats at a dose of 200 mg/kg body weight daily for the 21 days. Results: Stress induced by immobilization in the rats for 21 days decreased the passive avoidance behavior, total counts of RBCs, WBCs and brain AChEs activity. Upon co-administration of CA leaves extract to the stressed animals significantly reverted the changes to near normal levels when compared to control animals. Conclusion: Aqueous extract of CA leaves significantly reverted the changes due to immobilization induced stress which may be due to the anti-stress activities of CA leaves.


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