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ORIGINAL ARTICLE
Year : 2013  |  Volume : 3  |  Issue : 1  |  Page : 17-23

Red wine, white wine, rosé wine, and grape juice inhibit angiotensin-converting enzyme in human endothelial cells


Department of Medical and Health Sciences, Division of Drug Research/Pharmacology, Faculty of Health Sciences, Linköping University, Sweden

Correspondence Address:
Ingrid Persson
Department of Medical and Health Sciences, Division of Drug Research/Pharmacology, Faculty of Health Sciences, Linköping University, SE-581 85 Linköping
Sweden
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.106975

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Background: Beneficial effects of wine on cardiovascular disease have been shown previously, but the mechanism is still unknown. The renin-angiotensin system is an important mechanism in the body concerning regulation of blood pressure, fluid, and electrolyte balance, and the angiotensin-converting enzyme (ACE) is a key enzyme in this system. Aims: The aim of this study was to investigate the effect of red wine, white wine, rosι wine, and alcohol-free grape juice on somatic ACE-1 activity. The effects of the stilbene resveratrol and its glycoside, resveratrol-3-glycoside were also tested on ACE activity and concentration of nitric oxide (NO). Materials and Methods: Cultured endothelial cells from human umbilical veins (HUVEC) were incubated with wine, grape juice, resveratrol, or resveratrol-3-glycoside. Ethanol was used as control in the corresponding concentration (13%). Results: After incubation, a significant inhibition of ACE activity was seen with all the wines tested and the red grape juice. This inhibition was of a similar magnitude except for a lesser inhibition with the rosι wine. No significant inhibition was seen with the white grape juice, resveratrol, resveratrol-3-glycoside, or ethanol alone, and neither did resveratrol nor resveratrol-3-glycoside affect the concentration of NO. Conclusions: The effect of wine and grape juice on ACE activity in HUVEC is dependent on the amount of flavonoids and not on the content of alcohol or resveratrol.


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