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ORIGINAL ARTICLE
Year : 2012  |  Volume : 2  |  Issue : 3  |  Page : 243-250

Study of cardiovascular effects of caffeine in healthy human subjects, with special reference to pulse wave velocity using photoplethysmography


ICMR Advanced Centre for Clinical Pharmacodynamics, Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, India

Correspondence Address:
Raveendranadh Pilli
ICMR Advanced Centre for Clinical Pharmacodynamics, Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.99478

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Introduction: Caffeine is one of the most widely used pharmacologically active substances. It increases blood pressure and peripheral vascular resistance by stimulation of the sympathetic nervous system. Studies on the cardiovascular effects of caffeine have often produced contradictory results. Arterial stiffness and pulse wave reflections are important determinants of the efficient performance of the cardiovascular system, with prognostic value for cardiovascular risk. Materials and Methods: This is a randomized, double-blind, placebo-controlled, parallel-design study, comparing the effects of a single oral dose of 250 mg or 500 mg caffeine and placebo on arterial stiffness and pulse wave reflections in 36 healthy male subjects by measuring arterial pulse wave velocity by recording fingertip second derivative of photoplethysmogram (SDPTG) and ECG simultaneously. Blood pressure, heart rate, pulse wave velocity, and b/a ratio (SDPTG index) were measured at baseline and at 30 and 60 minutes after administration of caffeine. Results: Compared to baseline, systolic and diastolic blood pressures were increased significantly at 30 minutes and 60 minutes with caffeine, while heart rate decreased significantly at 30 minutes (P<0.05 for 250mg and P<0.01 for 500mg caffeine) but showed no significant change at 60 minutes. Pulse wave velocity increased significantly with both the doses of caffeine at 30 minutes (P<0.05) and 60 minutes (P<0.001). Similarly, the b/a ratio also increased significantly at 30 minutes (P<0.01) and 60 minutes (P<0.01) with 250 mg, but the change was insignificant with 500 mg. No significant changes were observed after administration of placebo. Conclusion: Acute administration of caffeine produced rise in blood pressure, arterial stiffness, and change in wave reflections in healthy subjects as indicated by pulse wave velocity and b/a ratio.


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