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ORIGINAL ARTICLE
Year : 2012  |  Volume : 2  |  Issue : 2  |  Page : 111-120

Neuroprotective effect of cow colostrum and tetramethylpyrazine against global cerebral ischemia reperfusion injury


Department of Pharmacology, Pune District Education Association's Seth Govind Raghunath Sable College of Pharmacy, Saswad, SNJB's Shriman Sureshdada Jain College of Pharmacy, Chandwad, Nashik, Maharashtra, India

Correspondence Address:
Vaishali R Undale
Department of Pharmacology, PDEA's SGRS College of Pharmacy, Saswad, Maharashtra - 412 301
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.95947

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Aim: Cerebral ischemia is the third leading cause of death in the western world. According to the WHO 15 million of the world's population suffer cerebral ischemia each year. The aim of the present study was to investigate the effect of tetramethylpyrazine (TMP) and cow colostrum in bilateral common carotid artery occlusion (BCCAO)-induced global ischemia-reperfusion injury. Cow colostrum is claimed to have antioxidant effects and TMP is popularly used in the treatment of cardiovascular diseases. Materials and Methods: Male Sprague-Dawley rats weighing 300350 g were treated with cow colostrum (125, 250, and 500 mg/kg) and TMP (12.5, 25, and 50 mg/kg) for 7 days after cerebral ischemia induced by BCCAO for 30 minute followed by reperfusion. Results: A significant decrease in body weights and marked weakness in the ischemic animals were observed. These effects were attenuated by cow colostrum (500 mg/kg) and TMP (25 and 50 mg/kg). There was significant increase in the level of malondialdehyde (MDA) and attenuation in the levels of reduced glutathione (GSH) and catalase in ischemic animals, indicating oxidative stress. Elevated levels of MDA and attenuated levels of GSH and catalase were compensated by treatment with cow colostrum and TMP dose dependently. Overall, the results of the study indicate that at doses of 25 mg/kg and 50 mg/kg TMP markedly improves cognition. The results also indicate that both TMP and cow colostrum have antioxidant activity. Conclusion: This study demonstrates the neuroprotective potential of cow colostrum and TMP. They appear to be promising drugs for the prophylaxis and treatment of global cerebral ischemia.


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