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ORIGINAL ARTICLE
Year : 2012  |  Volume : 2  |  Issue : 2  |  Page : 105-110

Antidiabetic activity of Pandanus fascicularis Lamk - aerial roots in alloxan-induced hyperglycemic rats


1 Institute of Pharmacy, Bundelkhand University, Kanpur Road, Jhansi, Uttar Pradesh, India
2 National Research Institute for Ayurveda Siddha Human Resource Development Aamkho, Gwalior, Madhya Pradesh, India

Correspondence Address:
Savita Kumari
Institute of Pharmacy, Bundelkhand University, Kanpur Road, Jhansi, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.95943

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Background: The aerial roots of Pandanus fascicularis are used traditionally in treatment of diabetes. Objective: This study evaluated the antidiabetic activity of methanolic extract of aerial roots of P. fascicularis. Materials and Methods: Effect of methanolic extract of roots of P. fascicularis on normal blood glucose levels and oral glucose tolerance test were studied in normoglycemic rats while antidiabetic effect was evaluated in alloxan-induced hyperglycemic rats. The extract (250, 500, and 1000 mg/kg) was administered orally for 7 days. Glibenclamide (3 mg/kg, orally for 7 days) was used as reference standard. Results: Administration of the methanolic extract of aerial roots of P. fascicularis caused significant dose-dependent reduction in serum glucose in both normoglycemic and hyperglycemic rats and also improved glucose tolerance test. The treatment also showed the enhanced beta cell function in histological studies. Conclusion: Therefore, this study suggests that methanolic extract of aerial roots of P. fascicularis exhibits antidiabetic activity possibly through increased secretion of insulin and the effect may be due to the presence of flavonoids and phenolic compounds.


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