Users Online: 842

Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 
     
ORIGINAL ARTICLE
Year : 2012  |  Volume : 2  |  Issue : 1  |  Page : 26-30

Effect of cold stimulation-induced pain on pharmacodynamic responses in healthy human volunteers


ICMR Advance Center for Clinical Pharmacodynamics, Departments of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Pingali Usha Rani
Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad 500 082, Andhra Pradesh
India
Login to access the Email id

Source of Support: Indian Council of Medical Research., Conflict of Interest: None


DOI: 10.4103/2231-0738.93129

Rights and Permissions

Aims: The aim of the present study was to quantify the changes in pharmacodynamic response during cold stimulation-induced pain. Materials and Methods: In the present study we evaluated the effect of cold stimulation (immersion of hand into cold water, 1 ± 0.5°C) in 24 healthy human subjects. Change in skin conductance (in the form of galvanic skin response), skin temperature, and heart rate were recorded using the Data Acquisition System (Biopac mp 150). Results: There was significant increase in skin conductance (P<0.001) from 0.22 ± 0.19 microSiemens to 0.32 ± 0.27 microSiemens, with 58.3% increase from the baseline. The heart rate also significantly increased by 8.3% (P<0.001) from 85.6 ± 15.1 bpm to 92.2 ± 14.2 bpm. There was no significant change in skin temperature. Conclusion: The findings of this study showed that an increase in skin conductance seemed to be a good indicator of acute pain. The changes in skin conductance were influenced by acute pain; therefore, monitoring skin conductance could be used as a pharmacodynamic parameter in the evaluation of analgesic agents.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3074    
    Printed164    
    Emailed0    
    PDF Downloaded82    
    Comments [Add]    

Recommend this journal