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ORIGINAL ARTICLE
Year : 2011  |  Volume : 1  |  Issue : 2  |  Page : 174-178

Impact of morin (a bioflavonoid) on ammonium chloride-mediated oxidative damage in rat kidney


Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India

Correspondence Address:
Perumal Subramanian
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamil Nadu
India
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Source of Support: Indian Council of Medical Research (ICMR), New Delhi., Conflict of Interest: None


DOI: 10.4103/2231-0738.84210

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Introduction : Hyperammonemia is a major contributing factor to neurological abnormalities observed in hepatic encephalopathy and in congenital defects of ammonia detoxification. Ammonia toxicity results in free radical generation that leads to oxidative stress and tissue damage. Morin is a bioflavonoid, a constituent of many herbs and fruits that are used as herbal medicines and also several biological activities. Our aim is to investigate the effect of morin on blood ammonia and plasma urea as well as kidney lipid peroxidation, and the antioxidant status in ammonium chloride-induced hyperammonemic rats. Materials and Methods: Male albino Wistar rats weighing 180 - 200 g were used for the study. Hyperammonemia was induced by interaperitonial injection of ammonium chloride (100 mg / kg body weight). The rats were treated with morin (30 mg / kg body weight) via oral administration. Administration of morin in hyperammonemic rats reduced the levels of ammonia and urea. The antioxidant property of morin was studied by assessing the activities of thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP), conjugated dienes (CD), and antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) in ammonium chloride-treated rats. Results and Conclusions: Kidney oxidative stress was effectively modulated by morin administration. Morin significantly improved the status of kidney antioxidants and decreased the levels of ammonia, urea, TBARS, HP, and CD, as compared to the ammonium chloride-treated group. The study offers evidence for the antihyperammonemic and antioxidant effects of morin against oxidative stress in the kidney, induced by ammonium chloride.


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