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ORIGINAL ARTICLE
Year : 2011  |  Volume : 1  |  Issue : 2  |  Page : 152-156

Antidepressant like activity of Lagenaria siceraria (Molina) Standley fruits by evaluation of the forced swim behavior in rats


1 Department of Pharmaceutical sciences, Bhagwan Mahavir College of Pharmacy, Surat, Gujarat, India
2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India

Correspondence Address:
Rakesh Prajapati
Department of Pharmaceutical sciences Bhagwan Mahavir College of Pharmacy, Surat, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.84206

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Context : In current stressful routine life, depression has become the second most common chronic condition in clinical psychology practice. Lagenaria siceraria (Molina) Standley (LS), commonly known as ''bottle gourd'' (English), possesses several medicinal properties; little is known about its traditional use as nerve tonic. Objective: The purpose of the study was to evaluate the antidepressant activity of methanolic extract of Lagenaria siceraria (Molina) Standley fruits (MLSF) using forced swim (behavior despair) models. Materials and Methods: LS fruit slices were dried and extracted with methanol in Soxhlet apparatus for 5-6 h. Adult Wistar albino rats were subjected to behavior despair test. Imipramine was used as reference standard drug. Results and Discussion: The MLSF (50, 100, and 200 mg/kg, p.o.) showed dose-dependent significant reduction in duration of immobility (P < 0.01) in behavior despair test. The phytochemical screening revealed the presence of phytoconstituents, such as flavonoids, saponins, and sterols in the fruits. Conclusions: The results of the study for show that the plant possesses antidepressant activity, confirming the traditional claims. Future research should focus on the isolation and identification of the phytoconstituents responsible for the antidepressant activity of LS .


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