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ORIGINAL ARTICLE
Year : 2011  |  Volume : 1  |  Issue : 2  |  Page : 146-151

Tephrosia purpureaLinn leaves attenuate pain and inflammation in experimental animals


1 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik; Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamil Nadu, India
2 Department of Pharmacology, Nandha College of Pharmacy, Erode, Tamil Nadu, India
3 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, India

Correspondence Address:
Vishal Gulecha
Department of Pharmacology, SNJB'S SSDJ College of Pharmacy Neminagar, Chandwad, Nashik
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.84205

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Aim : Present study evaluates the analgesic and anti-inflammatory activities of different fractions of Tephrosia purpurea using various experimental models. Materials and Methods: The analgesic activity of T. purpurea carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. The effects of the administration of reference standard (Ibuprofen and hydrocortisone) were also evaluated. Results: Five different fractions (TPI, TPII, TPIII, TPIV, and TPV) of T. purpurea at the dose level of 20 and 40 mg/kg, p.o. were tested. The fraction TPI (40 mg/kg, p.o.) and TPIII (40 mg/kg, p.o.) were found to be more effective in preventing carrageenan induced rat paw edema, cotton pellet granuloma formation and acetic acid-induced writhing; however, TPI (20 mg/kg, p.o.) and TPIII (20 mg/kg, p.o.) were found to be more effective in increasing latency period in tail flick method. Conclusions: Out of five different fractions of T. purpurea tested, TPI and TPIII possess potent analgesic and anti-inflammatory activities against different models of inflammation and pain.


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