Users Online: 1621

Home Print this page Email this page Small font sizeDefault font sizeIncrease font size

Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 
     
ORIGINAL ARTICLE
Year : 2011  |  Volume : 1  |  Issue : 2  |  Page : 139-145

1-methyl 4 -phenyl 1,2,3,6-tetrahydropyridine is a potent neurotoxin: Gamma-tocopherol recuperate behavior, dopamine, and oxidative stress on Parkinsonic mice


1 Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, Tamil Nadu, India
2 Department of Biochemistry, Regensberg University, Germany

Correspondence Address:
Tamilarasan Manivasagam
Biotechnology, Annamalai University, Annamalai Nagar- 608 002, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.84204

Rights and Permissions

Aim : The present study was designed to investigate the neuroprotective effect of gamma-tocopherol on MPTP induced Parkinsonic mice. Materials and Methods: Oral administration of γ-tocopherol (48 mg/kg BW) in C57BL/6 mice for seven days. Parkinson's disease was induced by four intraperitoneal injections (from 4th to 7th day) of MPTP (30 mg/kg BW). On the end of experiment (8th day), behavioral studies were performed to understand motor skill abnormalities and then animals were sacrificed to procure midbrain and striatum. Subsequently, homogenized and centrifuged to get postmitochondrial supernatant which was used to assay a) Neurochemical -- Dopamine, DOPAC, HVA b) Biochemical -- TBARS, GSH, GPx, SOD, and Catalase. Results: Pretreatment of γ-tocopherol (48 mg/kg BW) significantly attenuated the MPTP induced behavioral (rotarod performance, open field test, narrow beam walk test and hang test), neurochemical, biochemical alterations in mice suggesting their free-radical scavenging potential. Conclusions: Our results demonstrate that γ-tocopherol confers potent neuroprotection against MPTP-induced toxicity of dopaminergic neurons, and may become a potential therapeutic strategy for neurodegenerative disorder such as Parkinson's disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3698    
    Printed182    
    Emailed1    
    PDF Downloaded253    
    Comments [Add]    
    Cited by others 6    

Recommend this journal