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ORIGINAL ARTICLE
Year : 2011  |  Volume : 1  |  Issue : 1  |  Page : 69-72

Role of Barley in the improvement of Nephrocalcinosis in experimental rabbit model


1 Department of Pharmacology and Therapeutics, Al-Yarmouk University, Baghdad, Iraq
2 Department of Pharmacology, Al- Diwanyia University, Al- Diwanyia, Iraq

Correspondence Address:
Rafi A.M. Al-Razzuqi
Department of Pharmacology and Therapeutics, Al-Yarmouk University, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.77535

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Introduction: Nephrocalcinosis is a state of deposition of calcium phosphate or oxalate in the renal parenchyma. It may occur in patients with renal tubular acidosis, vitamin D intoxication, and hyperparathyroidism. Aim: According to traditional medicine, which mentioned Barley as a herbal remedy for relieving renal pain, we attempted to evaluate the effectiveness of barley in improving nephrocalcinosis induced by a large dose of oxalic acid in a rabbit model. Materials and Methods: Fourteen healthy rabbits were allocated to two groups. 2 hours before induction of nephrocalcinosis, a group received water and the other received aqueous extract of barley and continued feeding for ten days. Blood samples were collected for biochemical analysis before induction and in the tenth post-induction day. Urine samples were taken to estimate urinary ca+2 levels and crystals. The histopathological examination was carried to check for crystal deposits in renal tissues. Results: The results showed a significant reduction in blood urea nitrogen and serum Na+ levels with insignificant change in serum creatinine and K+ in comparison with the control group. It revealed a significant reduction in calcium deposition from renal parenchyma after 10 days of treatment, with improvement in nephrocalcinosis severity. Conclusion: Barley showed a significant diuretic and attenuating effect on reducing calcium deposits from renal parenchyma.


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