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ORIGINAL ARTICLE
Year : 2011  |  Volume : 1  |  Issue : 1  |  Page : 51-55

Influence of thymoquinone on glycoprotein changes in experimental hyperglycemic rats


Department of Biochemistry and Biotechnology, Annamalai University, Annamalai nagar, Tamil Nadu, India

Correspondence Address:
Leelavinothan Pari
Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar - 608 002, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2231-0738.77532

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Aim: The present study was designed to investigate the effect of thymoquinone (TQ) on the levels of glycoprotein components in plasma and tissues of streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats. Materials and Methods: Diabetes was induced in experimental rats by a single intraperitoneal (i.p) injection of STZ (45 mg/kg b.w) dissolved in 0.1 M citrate buffer (pH 4.5) 15 minutes after the i.p injection of NA (110 mg/kg b.w). Results: The levels of hexose, hexosamine, fucose, and sialic acid were estimated in plasma, liver, and kidney tissues of experimental rats. An increase in glycoprotein components in plasma was noticed in diabetic rats. In hepatic and renal tissues, a significant decrease in sialic acid with increases in hexose, hexosamine, and fucose levels were observed in diabetic rats when compared with control animals. Oral administration of TQ at 80 mg/kg b.w. for 45 days significantly ameliorated the glycoprotein changes in plasma and tissues of diabetic rats. Conclusion: The results of the present study show the potent beneficial effects of TQ in modifying the levels of glycoprotein components in plasma and tissues of diabetic rats.


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